Programa de Pós-Graduação em Farmacologia e Química Medicinal
Required Courses for Master's Degree:
BMF712 – Didactic Training
Course load: 45 hours – 3 credits
Course program: Didactic training of students under the supervision of the teacher in charge and the student's advisor. Students must participate in seminars and practical classes offered to undergraduate students and must prepare and teach a theoretical class under the supervision of the faculty of the pharmacology program on a topic chosen by the coordinator. The evaluation is carried out by a committee of professors from the PPGFQM.
BMF717 – Journal of Data
Course load: 45 hours – 3 credits
Course program: The student must present seminars on scientific articles, as well as on personal experimental data, being guided by different course professors and judged by the professors present.
BMF731 – Experimental Work I
Course load: 90 hours – 6 credits
Course program: The student will be evaluated by the advisor professor when starting the experimental part of his Thesis/Dissertation work (second and third semester of the course).
BMF732 – Experimental Work II
Course load: 90 hours – 6 credits
Course Description: The student will be evaluated by the advisor professor when starting the experimental part of his Thesis/Dissertation work (second and third semester of the course).
BMF750 – Bioethics, biosafety, and good practices with experimental animals
Course load: 30 hours – 2 credits
Required Courses for Doctor's Degree:
BMF755 – Didactic Training II
Course load: 45 hours – 3 credits
Course Description: Didactic Training of Doctoral students who must, under the guidance and supervision of the professor in charge and the advisor, prepare and teach theoretical classes and participate in seminars and practical classes in the classroom applied regularly to the undergraduate disciplines in the pharmacology of courses (Medicine, Pharmacy, Dentistry, Nursing, Nutrition, Psychology, Biological Sciences – Medical Modality), offered by UFRJ. The evaluation will include the analysis of the professor responsible for the course and a poll of the students.
BMF812 – Didactic Training III
Course load: 45 hours – 3 credits
Course Description: Didactic Training for Doctoral students who must, under the guidance and supervision of the responsible professor and advisor, prepare and teach theoretical classes and participate in seminars and practical classes in the classroom applied regularly to undergraduate disciplines in pharmacology, offered by UFRJ.
BMF831 – Experimental Work III
Course load: 180 hours in practice – 12 credits
Course Description: Experimental Doctoral work, evaluated by the advisor when the student completes the experimental results part of the thesis.
BMF750 – Bioethics, biosafety, and good practices with experimental animals
Course load: 30 hours – 2 credits
Elective Courses:
BMF701 - Advanced Studies in Pulmonary Inflammation
Course load: 30 hours - 2 credits
Course program: The course aims to provide basic principles about the mechanisms involved in the triggering, maintenance and resolution of the inflammatory process and address specific aspects of chronic inflammatory lung diseases.
BMF-703 – Pharmacology of the Renin-Angiotensin System
Course load: 45 hours – 3 credits
Course program: A disciplina tem por objetivo apresentar alvos moleculares para a regulação farmacológica do sistema renina Angiotensina Aldosterona em diversas patologias que envolvem os sistemas cardiovascular.
BMF706 — Methods in Pharmacokinetics
Course load: 45 hours – 3 credits
Course program: Fundamentos das vias de administração de fármacos; distribuição e eliminação (efeito de pH na eliminação de ácidos fracos); construção de curvas dose-efeito e investigação da relação dose-efeito in vivo e in vitro; demonstrar os princípios de interações farmacológicas.
BMF708 – Master's Dissertation Research
Course load: 0 horas – 0 créditos
Course program: Trabalho individual de pesquisa sob supervisão do orientador acadêmico. Obrigatória para alunos com créditos de disciplinas já concluídas.
BMF711 – Seminars in Immunopharmacology
Course load: 45 hours – 3 credits
Course program: Seminars are presented by all laboratory students (IC, masters and doctoral students) on topics related to their projects. This discipline aims to encourage students to read recently published works, thus keeping them up to date.
BMF-713 – Introduction to Drug Patents
Course load: 30 hours – 2 credits
Course program: 1° Introduction to the concepts of discovery, invention and innovation; 2° Appropriation of knowledge; 3° The patent system; 4th Law 9279/96; 5° Patentability requirements; 6° Directives and normative instructions; 7° Chemical compounds; 8° Stereoisomers; 9° Polymorphs; 10° Solvates, clathrates, co-crystals; 11° Compositions, formulations and physical forms; 12° Combinations of compounds; 13th Processes; 14° New uses of known products.
BMF717 – Ten Minutes Talk
Course load: 30 hours – 2 credits
Course program: The course aims to guide and prepare graduate students (master's and doctoral level) to give a short 10-minute oral presentation in English. The lecture must have scientific rigor and may be about the student's research topic or about a subject of interest. In addition to the short lecture, students will be encouraged to communicate with each other and with the teacher (tutor) in English during face-to-face meetings.
BMF719 – Molecular Pharmacology of Ionotropic Receptors
Course load: 45 hours – 3 credits
Course program: Classification. Study methods: electrophysiology, binding assays, isotope fluxes, ion fluorimetry and molecular biology. Molecular structure. Microscopic kinetics of drug-receptor interaction. Ionotropic receptors for acetylcholine, glutamate, GABA and others.
BMF-724 – Test Methods in Cardiovascular Pharmacology
Course load: 45 hours – 3 credits
Course program: Methodology for the research of substances with action potential in the heart and vessels. Langendorff technique, isolated papillary muscle, isometric tension in artery and vein, in vivo blood pressure and electrocardiogram recording, skinned fiber, and current recording.
BMF-726 – Test Methods in Neuropharmacology
Course load: 45 hours – 3 credits
Course program: Testing of substances with anticonvulsant, sedative, hypnotic, anxiolytic, and anesthetic activity. Learning and memory investigation method. Electrophysiological methods are applied to research the activity of cells located in the central nervous system.
BMF-727 – Special Topics in Medicinal Chemistry I
Course load: 15 hours – 1 credit
Course program: The subject will deal, in the indicated workload, with advanced topics in medicinal chemistry from the critical eye of specialist researchers in the area, who will act as guest professors (national and/or international).
BMF-733 – NMR in Drug Analysis and Planning
Course load: 30 hours – 2 credits
Course program: Nuclear Magnetic Resonance is one of the techniques most used by chemists for structural elucidation. Its advancement in terms of equipment and pulse sequences has allowed its application to be disseminated in others such as Medicinal Chemistry, Biochemistry, Internal Medicine, and Microbiology, among others. This discipline will promote the basic training necessary for the student to understand the operation of the technique and its most modern applications, giving him the opportunity to understand experiments and future applications that will allow him to always expand his knowledge in order to interact with the various areas of application.
BMF-735 – Binding, Receptores e Screening
Course load: 45 hours – 3 credits
Course program: Study of pharmacological receptors through the binding of radioactive molecules. Equilibrium study (direct and competition) and association and dissociation kinetics. Multiple receptors, positive and negative cooperativity. Theoretical aspects and practical considerations. Practical demonstration with computerized analysis of the results. Non-linear regression. Binding assays for screening new molecules.
BMF-736 – Methods for Studying the Inflammatory Process and Pain
Course load: 45 hours – 3 credits
Course program: Seminars and practical lectures on classical techniques for studying the inflammatory process (edema, pleurisy, vascular permeability, migration) and the painful process (withdrawal of the tail, hot plate).
BMF737 – Special Topics in Pharmacology I
Course load: 15 hours – 1 credit
Course program: The discipline will deal, in the indicated workload, with advanced topics in medicinal chemistry and from the critical eye of specialist researchers in the area, who will act as guest professors (national and/or international)
BMF-738 – Tópicos Especiais em Química Medicinal II
Course load: 30 hours – 2 credits
Course program: The subject will deal, in the indicated workload, with advanced topics in medicinal chemistry and from the critical eye of specialist researchers in the area, who will act as guest professors (national and/or international)
BMF-739 – Special Topics III
Course load: 30 hours – 2 credits
Course program: Elective subject offered occasionally, when it is possible to take advantage of the presence of external researcher(s) to elaborate a program of activities related to GP.
BMF740 – Special Topics in Pharmacology II
Course load: 30 hours – 2 credits
Course program: The subject will deal, in the indicated workload, with advanced topics in molecular and/or preclinical and/or clinical pharmacology from the critical eye of specialist researchers in the area, who will act as guest professors (national and/or international).
BMF741 – Special Topics in Medicinal Chemistry I
Course load: 15 hours -1 credit
Course program: The subject will address, in an integrated and interdisciplinary manner, advanced topics in pharmacology and medicinal chemistry, which will be presented by researchers from outside the country, and specialists in the areas, with a focus on the chain of innovation in pharmaceuticals. It will be offered as part of the "International Symposium on Pharmacology and Medicinal Chemistry (ISPMec)", organized by the Graduate Program in Pharmacology and Medicinal Chemistry (PPGFQM).
BMF742 – Practical Course in Pharmacology
Course load: 15 hours –1 credit
Course program: The Practical Course in Pharmacology proposes to offer practical classes in various subjects of Pharmacology, for undergraduate students from teaching institutions, public and private throughout the national territory. Degree in Pharmacology and Medicinal Chemistry.
BMF-743 – Inflammation and Cell Signaling
Course load: 45 hours – 3 credits
Course program: Signalers of inflammatory processes: eicosanoids, cytokines, nitric oxide. Cell growth factors. Cell adhesion processes: adhesion molecules, integrins.
BMF744 – Scientific Dissemination I
Course load: 60 hours – 4 credits
Course program: The subject proposes to prepare dissemination material on a topic to be chosen and to present the theme chosen by the public school system in Rio de Janeiro.
BMF746 – Pharmacology of Metabotropic Receptors
Course load: 45 hours – 3 credits
Course program: The course aims to study receptors coupled to the G/7TM protein, addressing structure, types, and distribution. Bioactive lipids, protein kinases, canonical and non-canonical cell signaling, and functional selectivity are also discussed.
BMF-747 – Highlights in Medicinal Chemistry
Course load: 15 hours – 1 credit
Course program: The proposal of this discipline is to learn different actual hot topics of medicinal chemistry and drug design and the discovery process through the presentation of lectures by invited international speakers or visiting professors.
BMF749 - Drug Discovery and Development Process
Course load: 30 hours – 2 credits
Course program: The aim of this course is to provide playful and interactive learning about the long and costly process that leads to the commercialization of new drugs, with particular emphasis on the different stages of the discovery phase and the pre-clinical phase. With this, it is expected that at the end of the game, the students will have learned the different tasks to be performed, for each of the steps that constitute the drug discovery and development phases, within the regulatory framework. It is also expected that players have learned or improved their knowledge regarding the practical aspects of different types of essays as well as the terminology used in this multidisciplinary area. The discipline uses the SCREENER educational game as a tool, a board game specially developed for this purpose and endorsed by the SBFTE.
BMF-751 – Neurodegenerative Diseases
Course load: 45 hours – 3 credits
Course program: General concepts about neurodegenerative and neuropsychiatric diseases, general principles of behavioral tests applied to scientific research.
BMF762 – Writing scientific papers
Course load: 45 hours – 3credits
Course program: Address relevant aspects of formalism in writing reports, dissertations, theses, and scientific articles in different ways.
BMF-763 – Scientific methodology
Course load: 45 hours – 3 credits
Course program: Addresses aspects related to scientific methods and ethics in science.
BMF-765 – Medicinal Chemistry
Course load: 90 hours – 6 credits
Course program: It deals with molecular aspects and their structural relationship with biomacromolecules of the biophase, aiming at understanding the relationship between chemical structure and therapeutic activity.
BMF767 – Chemical Structure and Pharmacokinetic Property of Drugs
Course load: 30 hours – 2 credits
Course program: Introduce a critical view of the relationship between chemical structure and pharmacokinetics of bioactive compounds. Strategies for predicting and optimizing the pharmacokinetic properties of drug candidates. Study of ADMET properties.
BMF-769 – Structure and Stereochemistry of Drugs
Course load: 45 hours - 3 credits
Course program: The course aims to introduce the concepts of stereochemistry and the understanding of the relationships between structural factors and the biological activity of drugs, including the study of conformational aspects involved in molecular recognition by the target bioreceptor.
BMF-770 – Drug Structure Analysis Methods
Course load: 30 hours – 2 credits
Course program: Discipline equivalent to the study of physical spectroscopic methods useful for the structural characterization of organic substances.
BMF773 — Use of animals in Experimentation
Course load: 45 hours – 3 credits
Course program: Ethical principles for the use of animals in research. Maintenance care and handling of animals in the laboratory and in vivariums. Analgesia, anesthesia and euthanasia in experimental animals.
BMF775 – Seminários Internacionais
Course load: 15 hours – 1 credit
Course program: The discipline offers students of the Graduate Program in Pharmacology and Medicinal Chemistry (PPGFQM) the possibility of attending seminars offered in English, within the scope of the Seminar Programs of the Institute of Medicines of the University of Lisbon (IMed-ULisboa, Portugal) , from the University of Tubingen (Germany) and from other foreign institutions collaborating with the PPGFQM.
BMF777 – Advanced Topics in Medicinal Chemistry
Course load: 45 hours – 3 credits
Course program: The course will deal with new aspects of medicinal chemistry related to the structural reasons for the activity of bioactive molecules.
BMF-778 – Special Topics in Pharmacology and Medicinal Chemistry II
Course load: 30 hours – 2 credits
Course program: The course will deal with advanced topics in medicinal chemistry through guest professors and experts in special topics of the course.
BMF-779 – Special Topics in Pharmacology and Medicinal Chemistry III
Course load: 45 hours – 3 credits
Course program: The course will deal with advanced topics in medicinal chemistry through guest professors and specialists in special topics of the course.
BMF-780 – Entrepreneurship, Science and Technology
Course load: 45 hours – 3 credits
Course program: This integrated course is aimed at teaching the practice of entrepreneurship. The course is inspired by two reference courses: the Lean Launchpad entrepreneurship course at the University of California Berkeley and the taught entrepreneurship course taught by the Center for Entrepreneurship at the Massachusetts Institute of Technology (MIT).
BMF782 – Structure and Toxicity of Drugs
Course load: 40 hours – 3 credits
Course program: It deals with structural and molecular aspects related to the toxicity of xenobiotics, including aspects related to the bioformation of reactive metabolites and other modulators of endogenous biomacromolecules.
BMF-785 – Molecular Basis of Drug Metabolism
Course load: 90 hours – 6 credits
Course program: Train and provide the molecular basis of the xenobiotic metabolism process with a focus on the biotransformation steps and the understanding of the importance and application of metabolism in the process of drug discovery.
BMF786 – Principles of Drug Synthesis
Course load: 45 hours – 3 credits
Course program: It aims to provide the basic principles of drug synthesis addressing selected examples over the past decades according to their innovative character in structural and pharmacological terms.
BMF-787 – Bioorganic Chemistry in Drug Development and Action
Course load: 30 hours – 2 credits
Course program: This course aims to introduce some modern concepts and techniques for drug design using computational chemistry, such as QSAR, docking, and molecular dynamics.
BMF-790 – PPGFQM Seminars
Course load: 45 hours – 3 credits
Course program: The PPGFQM seminar discipline foresees the integration of students with the different lines of research developed in the Program and aims at learning coexistence, dialogue, and interdisciplinary communication.
BMF-793 – Pharmacology of Toxins and Antagonists
Course load: 15 hours – 1 credit
Course program: The discipline introduces within pharmacology the concept of toxicology and the use of toxins or venoms from animals and plants investigated in models of cell injury in vitro or in vivo. It aims to make students aware of the venoms of the main venomous snakes of clinical importance, and the manifestations of poisoning by scorpions, spiders, and bees. It addresses the toxicity and different reactions of these processes, as well as the different substances that, together with antivenom serums, can prevent the effects of these toxic agents. In this subject, the student has the opportunity to study complex venoms with enzymatic activities (phospholipase, proteolytic, hyaluronidase, and collagenase activities) and inhibition by natural or synthetic substances. Reinforces the use of toxins as tools in the development of new drugs, whether from natural products or planned molecules that characterize the interaction of pharmacology and medicinal chemistry. We use international reference articles in toxicology/pharmacology and we also have practical bench experiments.
BMF-798 – Regulation of Intracellular Ca+2
Course load: 45 hours – 3 credits
Course program: Mechanisms of Ca+2 transport through the sarcolemma. Ryanodine receptor on the sarcoplasmic reticulum. Transport of Ca+2 by the sarcoplasmic reticulum (SERCA). IP3 receiver. Diseases that affect intracellular Ca2+ regulation.
BMF808 – Doctoral Thesis Research
Course load: 0 hours – 0 credits
Course program: Individual research work under the supervision of the academic advisor. Compulsory chair for students with credits from subjects already completed and who intend to present the thesis to obtain a Doctorate Diploma.
BMF814 – Scientific Guidance Training
Course load: 45 hours – 3 credits
Course program: Training in the orientation of laboratory interns for Ph.D. students. Activity is supervised and evaluated by the advisor, who must be the institution responsible for the intern.